Zebrafish Atp6v1a Antibody

The Atp6v1a protein forms the core of the V1 domain, where it contributes to ATP hydrolysis, driving proton translocation across membranes via the V0 domain. This acidification is essential for maintaining cellular homeostasis, lysosomal function, and pH-dependent signaling pathways. In zebrafish (Danio rerio), Atp6v1a is highly conserved and broadly expressed during development, particularly in neural, renal, and gastrointestinal tissues. It serves as a model for studying V-ATPase function in vertebrate development, organogenesis, and disease models such as neurodegeneration and cancer.