Zebrafish Bdnf Antibody / Brain-derived neurotrophic factor

Expression of Bdnf in zebrafish is observed early in embryogenesis and persists in various regions of the central nervous system, including the forebrain, optic tectum, and spinal cord. Zebrafish Bdnf interacts primarily with the high-affinity receptor TrkB (Ntrk2), activating intracellular signaling pathways such as PI3K-Akt, MAPK/ERK, and PLC-γ, which are essential for neurotrophic support and synaptic function. Due to the genetic tractability and optical transparency of zebrafish embryos, this model organism is widely used to investigate Bdnf-mediated neuronal development, behavior, and regeneration. Studies have also linked altered bdnf expression to stress responses, learning, and memory in zebrafish, highlighting its relevance in neurodevelopmental and neuropsychiatric research.