Zebrafish Hhex Antibody / Hex / Hematopoietically expressed homeobox protein

Hhex is expressed early in the developing embryo, particularly in regions that give rise to the anterior foregut and associated organs. It regulates the expression of key developmental genes involved in organogenesis and is required for proper morphogenesis of the thyroid gland and liver. In the developing brain, Hhex also contributes to the patterning of forebrain structures. Loss of Hhex function in zebrafish leads to defects in anterior endoderm formation, impaired thyroid and liver development, and abnormalities in forebrain organization. Because of its conserved function in vertebrate development, zebrafish Hhex serves as a valuable model for understanding congenital organ defects, endodermal lineage specification, and early tissue patterning. Zebrafish Hhex is widely used in developmental biology, stem cell research, and disease modeling, particularly in studies focused on endocrine and hepatic organ development.