Zebrafish Leo1 Antibody / RNA polymerase-associated protein LEO1

The Leo1 protein interacts with RNA polymerase two and other components of the transcription machinery to facilitate proper transcriptional progression and co transcriptional histone modifications. It is especially important in regulating genes involved in developmental pathways and stem cell maintenance. In zebrafish embryos, Leo1 is expressed in proliferative regions such as the developing brain, spinal cord, and somites. Functional studies have shown that disruption of Leo1 leads to defects in neural development, patterning of body structures, and cell cycle progression. These findings highlight its essential role in coordinating transcriptional programs during embryogenesis. Because of its conservation across vertebrate species and its involvement in fundamental gene regulatory processes, zebrafish Leo1 is widely used in studies of transcriptional control, developmental biology, and epigenetic regulation. It is also a useful target for exploring how dysregulation of transcription elongation may contribute to developmental disorders and diseases such as cancer.