Zebrafish Csf1r Antibody / M-csfr

Csf1r is activated by binding to its primary ligand, colony stimulating factor one, which triggers intracellular signaling pathways involved in cell survival, proliferation, and differentiation. In zebrafish, Csf1r is expressed in the yolk sac and hematopoietic tissues early in development and marks cells that give rise to macrophages, including microglia in the brain and Kupffer cells in the liver. Disruption of Csf1r function in zebrafish leads to reduced numbers or absence of tissue macrophages, providing a valuable model for studying the roles of these cells in development, immunity, and disease. Zebrafish Csf1r is widely used in research related to innate immunity, inflammation, neuroimmunology, and hematopoiesis. Due to its conservation across vertebrate species, zebrafish Csf1r is also a powerful tool for investigating genetic and pharmacological regulation of macrophage biology and for modeling diseases such as neurodegeneration and immune deficiencies.