Zebrafish Ornithine aminotransferase Antibody / Oat

In zebrafish, ornithine aminotransferase is expressed in multiple tissues including the liver, kidney, brain, and eye, reflecting its essential role in cellular homeostasis and metabolic balance. The zebrafish ornithine aminotransferase gene is an ortholog of the human OAT gene. Both proteins share high sequence similarity and conserved functional domains, supporting the use of zebrafish as a model for studying OAT related biology and disease. Functionally, ornithine aminotransferase is critical for regulating the intracellular balance of ornithine and proline, which are important for collagen synthesis, antioxidant responses, and retinal function. In humans, mutations in the OAT gene are associated with a rare metabolic disorder known as gyrate atrophy of the choroid and retina, which leads to progressive vision loss. Zebrafish models have been used to study the developmental and physiological consequences of OAT deficiency, especially in ocular and hepatic systems. Due to its evolutionary conservation and key metabolic functions, zebrafish ornithine aminotransferase is a valuable target in research areas including developmental biology, metabolism, neurobiology, and genetic disease modeling.