Zebrafish Ostf1 Antibody / Osteoclast-stimulating factor 1

In zebrafish, Ostf1 is strongly expressed in the gills, kidney, and other osmoregulatory organs, where it contributes to the adaptation of cells to changes in external ionic and osmotic conditions. Zebrafish Ostf1 is an ortholog of the human OSTF1 gene. Both zebrafish and human proteins share conserved structural features, including domains involved in transcriptional regulation and protein interactions. Functionally, Ostf1 acts as an intracellular signaling mediator that is activated in response to hyperosmotic stress. In zebrafish, it has been shown to regulate the expression of ion transporters and channels, including those involved in sodium and chloride balance. It may also contribute to the remodeling of gill epithelium and the function of mitochondrion-rich cells during osmotic adaptation. Ostf1 is also implicated in developmental processes and stress signaling pathways beyond osmoregulation. Because of its conservation and functional importance, zebrafish Ostf1 is widely used in studies of environmental stress physiology, aquaculture research, and basic cell signaling.