Zebrafish Otud5 Antibody / Otud5a / Otud5b

In zebrafish, Otud5 is expressed during early development and in various adult tissues, particularly in the nervous system, immune-related organs, and proliferative tissues. The zebrafish Otud5 protein is an ortholog of the human OTUD5 gene. Both proteins share conserved catalytic domains and regulatory motifs that are essential for deubiquitinase activity and interaction with signaling complexes. Functionally, Otud5 acts as a negative regulator of immune signaling by deubiquitinating and stabilizing key proteins in pathways such as type one interferon and nuclear factor kappa B signaling. It also influences chromatin accessibility and transcription by regulating histone modifiers and chromatin remodelers. In humans, mutations in OTUD5 have been linked to developmental disorders involving intellectual disability and immune dysfunction. In zebrafish, disruption of Otud5 function affects normal embryonic patterning and tissue development, suggesting a conserved role in regulating gene expression and cellular responses during growth and differentiation. Due to this conservation, zebrafish Otud5 is an important tool for modeling human disease mechanisms and studying deubiquitination in vertebrate development and immunity.