Zebrafish Pgam1 Antibody / Pgam1a / Pgam1b / Phosphoglycerate mutase

In zebrafish, Pgam1 is an ortholog of the human PGAM1 gene. Both zebrafish and human Pgam1 proteins share significant sequence similarity and perform equivalent functions in glycolytic metabolism. The protein in both species is involved in the reversible conversion of 3-phosphoglycerate to 2-phosphoglycerate, ensuring the smooth progression of glycolysis. Zebrafish Pgam1 is widely expressed in tissues that rely on high levels of metabolic activity, including the muscle, brain, and liver. Zebrafish Pgam1 has isoforms, as is common for metabolic enzymes involved in energy metabolism. These isoforms may differ in their tissue distribution or functional properties, which is important for the regulation of glycolysis under different physiological conditions. These isoforms may be involved in tissue-specific functions and are essential for maintaining glycolytic flux in response to varying energy demands during development and growth. In zebrafish, Pgam1 plays a critical role during embryogenesis, where metabolic regulation is essential for proper growth and tissue differentiation. It is also important for muscle development and neural tissue formation, where metabolic demands are high. Pgam1 is expressed in developing tissues, particularly those undergoing rapid cell division and differentiation. Given its role in metabolism, cellular energy regulation, and development, zebrafish Pgam1 is an important protein for studying glycolysis, energy metabolism, and diseases related to metabolic dysfunction. It is particularly valuable in studies of muscle metabolism, neurodevelopment, and embryonic development.