Zebrafish Sdha Antibody / Succinate dehydrogenase A

Zebrafish Sdha is an ortholog of the human SDHA protein and shares a high degree of sequence and functional conservation. In both species, Sdha functions as the catalytic subunit of succinate dehydrogenase and is required for efficient ATP generation. Mutations or disruptions in Sdha can impair mitochondrial function, leading to metabolic disorders and contributing to pathologies such as cancer and neurodegeneration. There is no evidence of multiple isoforms of zebrafish Sdha, and its structure and activity are highly conserved across vertebrates. The zebrafish model provides a valuable system for studying mitochondrial metabolism and diseases related to complex II dysfunction due to the evolutionary similarity to human SDHA. Antibodies against zebrafish Sdha protein are widely used as mitochondrial markers and for studying metabolic pathways. These antibodies are suitable for applications such as western blot, immunohistochemistry, immunofluorescence, and ELISA, enabling the investigation of mitochondrial dynamics and energy metabolism in zebrafish tissues.