Zebrafish Sod1 Antibody / Superoxide dismutase 1

Zebrafish Sod1 is an ortholog of the human SOD1 protein, sharing high sequence and functional conservation. Mutations in human SOD1 are well known for their link to amyotrophic lateral sclerosis (ALS), and zebrafish models expressing mutant Sod1 have been used extensively to study the mechanisms of neurodegeneration and oxidative stress. The conserved enzymatic function of Sod1 in zebrafish makes it a powerful model for investigating oxidative damage, neuronal health, and stress response pathways. There are no confirmed isoforms of zebrafish Sod1. The protein is expressed broadly in various tissues, with higher expression in metabolically active organs such as the brain, liver, and muscles where reactive oxygen species production is elevated. Its activity is tightly regulated, as both deficient and excessive reactive oxygen species can lead to cellular dysfunction. Antibodies targeting zebrafish Sod1 protein are important tools for studying oxidative stress pathways, mitochondrial function, and the effects of environmental or chemical stressors on cellular health. These antibodies are commonly used in applications such as western blot, immunohistochemistry, immunofluorescence, and ELISA to analyze Sod1 expression and regulation in zebrafish tissues.