TRP-1 Antibody / Tyrosinase-Related Protein-1
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1) . It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Product Specifications
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-3 µg/mL
UniProt
P17643
Host
Mouse
Reactivity
Human
Immunogen
SK-MEL-23 cells were used as the immunogen for the TRP-1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
SPM456
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Limitations
This TRP-1 antibody is available for research use only.
Storage Conditions
Aliquot the TRP-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the TRP-1 antibody should be determined by the researcher.
Location
Cytoplasm
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