Elastase 3A Antibody / CELA3A
Elastases belong to a subfamily of serine proteases that function to catalytically hydrolyze a wide variety of proteins. Elastase-3A, also known as ELA3A or ELA3, is a 270 amino acid protein that belongs to the elastase family and acts as an alanine-specific protease. Secreted as a zymogen from the pancreas, Elastase-3A functions as a digestive enzyme in the intestine that participates in metabolic degradation pathways by preferentially cleaving proteins that have alanine residues. In addition, Elastase-3A is thought to play a role in the metabolism and transport of cholesterol molecules in the intestine. Altered expression of Elastase-3A may be associated with pancreatic ductal carcinoma, a highly fatal cancer of the pancreatic ducts
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 1-2 µg/mL
UniProt
P09093
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 50-250 from human CELA3A protein was used as the immunogen for the Elastase 3A antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CELA3A/12552
Applications
IHC-P, WB
Purity
Protein G affinity
Format
Purified
Limitations
This Elastase 3A antibody is available for research use only.
Storage Conditions
Aliquot the Elastase 3A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Elastase 3A antibody should be determined by the researcher.
Location
Cytoplasm, Extracellular space
Image Legend
Western blot testing of human pancreas tissue lysate with Elastase 3A antibody (clone CELA3A/12552) . Predicted molecular weight ~29 kDa.
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