Podoplanin Antibody
Podoplanin is a transmembrane mucoprotein (38 kDa) recognized by the D2-40 monoclonal antibody. Podoplanin is specifically expressed in the endothelium of lymphatic capillaries but not in the blood vasculature. In normal skin and kidney, podoplanin is co-localized with VEGFR3/FLT4, another marker for lymphatic endothelial cells. Podoplanin is selectively expressed in lymphatic endothelium as well as Lymphangiomas, Kaposi’s Sarcomas and in subset Angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be expressed in Epithelioid Mesotheliomas, Hemangioblastomas and Seminomas.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q86YL7
Host
Mouse
Reactivity
Human
Immunogen
Resected tissue from dysgeminoma of the ovary was used as the immunogen for the Podoplanin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
D2-40
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Limitations
This Podoplanin antibody is available for research use only.
Storage Conditions
Aliquot the Podoplanin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Podoplanin antibody should be determined by the researcher.
Location
Cytoplasm, Membrane
Image Legend
Frequently Asked Questions
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