Periostin Antibody / POSTN
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for AlphaVbeta3 and AlphaVbeta5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF beta 1) . Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q15063
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 193-326 from human POSTN protein was used as the immunogen for the Periostin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
POSTN/4096
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Limitations
This Periostin antibody is available for research use only.
Storage Conditions
Aliquot the Periostin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Periostin antibody should be determined by the researcher.
Location
Secreted, Cytoplasm
Image Legend
Frequently Asked Questions
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