Cofilin 2 Antibody / CFL2
Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q9Y281
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-166 from human CFL2 protein was used as the immunogen for the Cofilin 2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CFL2/9963
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Limitations
This Cofilin 2 antibody is available for research use only.
Storage Conditions
Aliquot the Cofilin 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Cofilin 2 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Frequently Asked Questions
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