Decorin Antibody

Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFå°¾ and is a direct or indirect negative modulator of TGFå°¾ synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-çº¬ and TNFä¼ª may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. The human Decorin gene maps to chromosome 12q21.33 and encodes a 359 amino acid protein.

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P07585

Host

Mouse

Reactivity

Human

Immunogen

A recombinant human Decorin partial protein (within amino acids 212-336) was used as the immunogen for the Decorin antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

DCN/3521

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Limitations

This Decorin antibody is available for research use only.

Storage Conditions

Aliquot the Decorin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the Decorin antibody should be determined by the researcher.

Location

Secreted

Image Legend

Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using Decorin antibody (clone DCN/3521) . These results demonstrate the foremost specificity of the DCN/3521 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.