CD135 Antibody / FLT3
Stem cell tyrosine kinase (STK-1) has been cloned from a CD34+ hematopoietic stem cell enriched library and identified as the human homolog of a previously identified gene of Mouse origin designated either Flk-2 or Flt-3. The STK-1 cDNA encodes a protein of 993 amino acids with 85% identity to Flt-3/Flk-2. STK-1 is a member of the type III receptor tyrosine kinase family that includes Kit (steel factor receptor), Fms and PDGF. STK-1 expression in blood and marrow is restricted to CD34+ cells, a population greatly enriched for hematopoietic stem/progenitor cells. STK-1 antiserum recognizes two polypeptides in these cells. The Mouse homolog of STK-1, designated Flt-3/Flk-2, is expressed at high levels in hematopoietic cells and also in neural, gonadal, hepatic and placental tissues. It has been suggested that STK-1 and its murine homolog Flt-3/Flk-2 may function as growth factor receptors on hematopoietic stem and/or progenitor cells.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P36888
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 500-800 from human FLT3 protein was used as the immunogen for the CD135 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
FLT3/9888
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Limitations
This CD135 antibody is available for research use only.
Storage Conditions
Aliquot the CD135 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/cd135-antibody-flt3-flt39888-v5708
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD135 antibody should be determined by the researcher.
Location
Endoplasmic reticulum lumen, Membrane
Image Legend
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
