HSD17B13 Antibody / 7-beta hydroxysteroid dehydrogenase 13

Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) is an enzyme in the liver that is associated with lipid droplets. It is encoded by the HSD17B13 gene in humans. HSD17B13 levels increase in patients with non-alcoholic fatty liver disease (NAFLD) and can enhance lipogenesis. However, some studies have shown that loss-of-function variants in HSD17B13 may protect against the progression of NAFLD to non-alcoholic steatohepatitis, fibrosis, and hepatocellular carcinoma.

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q7Z5P4

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1-200 of the human protein was used as the immunogen for the HSD17B13 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

HSD17B13/13102

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Limitations

This HSD17B13 antibody is available for research use only.

Storage Conditions

Aliquot the HSD17B13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the HSD17B13 antibody should be determined by the researcher.

Location

Cytoplasm

Image Legend

IHC staining of FFPE human hepatocellular carcinoma tissue with HSD17B13 antibody (clone HSD17B13/13102) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.