17-beta-HSD 13 Antibody / HSD17B13

Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, 17-beta-HSD 13) is an enzyme in the liver that is associated with lipid droplets. It is encoded by the HSD17B13 gene in humans. HSD17B13 levels increase in patients with non-alcoholic fatty liver disease (NAFLD) and can enhance lipogenesis. However, some studies have shown that loss-of-function variants in HSD17B13 may protect against the progression of NAFLD to non-alcoholic steatohepatitis, fibrosis, and hepatocellular carcinoma.

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q7Z5P4

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1-200 of the human protein was used as the immunogen for the 17-beta-HSD 13 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

HSD17B13/13104

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Limitations

This 17-beta-HSD 13 antibody is available for research use only.

Storage Conditions

Aliquot the 17-beta-HSD 13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the 17-beta-HSD 13 antibody should be determined by the researcher.

Location

Cytoplasm

Image Legend

IHC staining of FFPE human hepatocellular carcinoma tissue with 17-beta-HSD 13 antibody (clone HSD17B13/13104) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.