Hydroxysteroid 17-beta dehydrogenase 13 Antibody / HSD17B13

Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) is an engyme in the liver that is associated with lipid droplets. It is encoded by the HSD17B13 gene in humans. HSD17B13 levels increase in patients with non-alcoholic fatty liver disease (NAFLD) and can enhance lipogenesis. However, some studies have shown that loss-of-function variants in HSD17B13 may protect against the progression of NAFLD to non-alcoholic steatohepatitis, fibrosis, and hepatocellular carcinoma.

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q7Z5P4

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1-200 of the human protein was used as the immunogen for the Hydroxysteroid 17-beta dehydrogenase 13 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

HSD17B13/13108

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Limitations

This Hydroxysteroid 17-beta dehydrogenase 13 antibody is available for research use only.

Storage Conditions

Aliquot the Hydroxysteroid 17-beta dehydrogenase 13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the Hydroxysteroid 17-beta dehydrogenase 13 antibody should be determined by the researcher.

Location

Cytoplasm

Image Legend

Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using Hydroxysteroid 17-beta dehydrogenase 13 antibody (clone HSD17B13/13108) . These results demonstrate the foremost specificity of the HSD17B13/13108 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.