KNG1 Antibody / Kininogen 1

Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. [UniProt]

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P01042

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1-200 from human Kininogen 1 protein was used as the immunogen for the KNG1 antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

KNG1/7422

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Limitations

This KNG1 antibody is available for research use only.

Storage Conditions

Aliquot the KNG1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the KNG1 antibody should be determined by the researcher.

Location

Extracellular, Secreted

Image Legend

IHC staining of FFPE human liver tissue with KNG1 antibody (clone KNG1/7422) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.