Liver Arginase Antibody / ARG1
Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1) . Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
P05089
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-200 from human ARG1 protein was used as the immunogen for the Liver Arginase antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
ARG1/9447
Applications
IHC-P, WB
Purity
Protein G affinity
Format
Purified
Limitations
This Liver Arginase antibody is available for research use only.
Storage Conditions
Aliquot the Liver Arginase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Liver Arginase antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human liver tissue lysate with Liver Arginase antibody (clone ARG1/9447) . Predicted molecular weight ~35 kDa.
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