Neural cell adhesion molecule L1 Antibody / NCAM-L1
L1 (L1 cell adhesion molecule) also known as CAML1, CD171, and HSAS is an adhesion molecule which plays an important role in the nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) . This mouse monoclonal antibody recognizes the sequence immediately NH2-terminal to the tyrosine-based motif and binds L1 only when Y1176 is dephosphorylated. Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
P32004
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 600-900 from human L1CAM protein was used as the immunogen for the Neural cell adhesion molecule L1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
L1CAM/13053R
Applications
IHC-P, WB
Purity
Protein A affinity
Format
Purified
Limitations
This Neural cell adhesion molecule L1 antibody is available for research use only.
Storage Conditions
Aliquot the Neural cell adhesion molecule L1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Neural cell adhesion molecule L1 antibody should be determined by the researcher.
Location
Cell surface, Cytoplasm
Image Legend
Frequently Asked Questions
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