PD-Ibeta Antibody / PDNP3 / ENPP3 / CD203c

Ecto-nucleotide pyrophosphatase/phosphodiesterase-I enzymes (E-NPP), a group of type II transmembrane proteins, cleave phosphodiester and phosphosulfate bonds in deoxynucleotides, NAD, and nucleotide sugars. There exist three closely related proteins in mammalian species: E-NPP1 (PC-1), E-NPP2 (PDNP2), and E-NPP-3 (PDNP3) which is also known as CD203c, each expressed in different cells or at different locations in the same cells. Basophils, a type of major proinflammatory effector cells involved in diverse pathologic reactions, exhibit CD203c expression. For instance, CD203c expression increases in response to a variety of allergens, including cat dander, latex, and bee and wasp venom. However, these allergies are not the only condition associated with CD203c upregulation; CD203c upregulation may also serve as a tumor marker for colon carcinoma.

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

O14638

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 300-600 from human ENPP3 protein was used as the immunogen for the PD-Ibeta antibody.

Clonality

Monoclonal

Isotype

IgG κ

Clone

ENPP3/9891

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Limitations

This PD-Ibeta antibody is available for research use only.

Storage Conditions

Aliquot the PD-Ibeta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the PD-Ibeta antibody should be determined by the researcher.

Location

Apical cell membrane, Cell membrane, Secreted

Image Legend

IHC staining of FFPE human kidney tissue with PD-Ibeta antibody (clone ENPP3/9891) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.