CD203c Antibody / ENPP3 / PD-Ibeta / PDNP3

Ecto-nucleotide pyrophosphatase/phosphodiesterase-I enzymes (E-NPP), a group of type II transmembrane proteins, cleave phosphodiester and phosphosulfate bonds in deoxynucleotides, NAD, and nucleotide sugars. There exist three closely related proteins in mammalian species: E-NPP1 (PC-1), E-NPP2 (PDNP2), and E-NPP-3, also known as CD203c, each expressed in different cells or at different locations in the same cells. Basophils, a type of major proinflammatory effector cells involved in diverse pathologic reactions, exhibit CD203c expression. For instance, CD203c expression increases in response to a variety of allergens, including cat dander, latex, and bee and wasp venom. However, these allergies are not the only condition associated with CD203c upregulation; CD203c upregulation may also serve as a tumor marker for colon carcinoma.

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

O14638

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 300-600 from human ENPP3 protein was used as the immunogen for the CD203c antibody.

Clonality

Monoclonal

Isotype

IgG κ

Clone

ENPP3/9892

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Limitations

This CD203c antibody is available for research use only.

Storage Conditions

Aliquot the CD203c antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the CD203c antibody should be determined by the researcher.

Location

Apical cell membrane, Cell membrane, Secreted

Image Legend

IHC staining of FFPE human kidney tissue with PD-Ibeta antibody (clone ENPP3/9892) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.