ACE2 Antibody / Angiotensin-Converting Enzyme 2

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Product Specifications

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q9BYF1

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1-300 from human ACE2 was used as the immunogen for the ACE2 antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

ACE2/7202

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Limitations

This ACE2 antibody is available for research use only.

Storage Conditions

Aliquot the ACE2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the ACE2 antibody should be determined by the researcher.

Location

Cell membrane, Secreted

Image Legend

IHC staining of FFPE human kidney tissue with ACE2 antibody (clone ACE2/7202) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.