BACH2 Antibody / BTB and CNC homology 2
Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Implicated in immunodeficiency 60. Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE) . Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation.
Product Specifications
Specifications
Flow cytometry: 1-2ug/million cells
UniProt
Q9BYV9
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 11-132 from human BACH2 protein was used as the immunogen for the BACH2 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
PCRP-BACH2-5B11
Applications
FACS
Purity
Protein G affinity
Format
Purified
Limitations
This BACH2 antibody is available for research use only.
Storage Conditions
Aliquot the BACH2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/bach2-antibody-btb-and-cnc-homology-2-pcrp-bach2-5b11-v5787
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the BACH2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
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