PGP9.5 Antibody / UchL1
This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1) . Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
P09936
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human UCHL1 protein was used as the immunogen for the PGP9.5 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
UCHL1/8153
Applications
IHC-P, WB
Purity
Protein G affinity
Format
Purified
Limitations
This PGP9.5 antibody is available for research use only.
Storage Conditions
Aliquot the PGP9.5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the PGP9.5 antibody should be determined by the researcher.
Location
Cytoplasm, Endoplasmic reticulum membrane
Image Legend
Western blot testing of human brain tissue lysate with PGP9.5 antibody (clone UCHL1/8153) . Predicted molecular weight ~25 kDa.
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