BAP1 Antibody / BRCA1-Associated Protein 1
The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q92560
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 400-729 from human BRCA1-Associated Protein 1 protein was used as the immunogen for the BAP1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
BAP1/9795R
Applications
IHC-P
Purity
Protein A affinity
Format
Purified
Limitations
This BAP1 antibody is available for research use only.
Storage Conditions
Aliquot the BAP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the BAP1 antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
Frequently Asked Questions
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