ANXA1 Antibody / Annexin A1
The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Product Specifications
Specifications
Western blot: 2-4 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P04083
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human Annexin A1 protein was used as the immunogen for the ANXA1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2b κ
Clone
RANXA1/9145
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Limitations
This ANXA1 antibody is available for research use only.
Storage Conditions
Aliquot the ANXA1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the ANXA1 antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
Western blot testing of human A549 cell lysate using ANXA1 antibody (clone rANXA1/9145) . Predicted molecular weight ~36 kDa.
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