Human NK2R Full Length Protein, Flag, His Tag (Detergent)
NK2R is a G protein-coupled receptor with high affinity for the tachykinin Substance K (Neurokinin A) . Upon activation, it triggers a phosphatidylinositol-calcium signaling pathway, leading to intracellular calcium release. The receptor's binding affinity follows the order: Substance K > Neuromedin K > Substance P. NK2R also regulates energy metabolism and has shown significant potential in appetite control. Due to its diverse functions, it is considered a promising therapeutic target for conditions such as asthma, irritable bowel syndrome, obesity, and type 2 diabetes.
Product Specifications
Background
Specifications
Expression Region
Gly 2 - Ile 398
Target
NK2R
Conjugation
Unconjugated
Tag
N-Flag & C-10xHis
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Purity
90%
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, Buffer B, CHS, pH7.5
Molecular Weight
47.9 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Host or Source
HEK293
Species
Human
Protein ID
P21452
Preservative
Glycerol
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