Human GPR146 Full Length Protein, His, Flag Tag (Detergent)
GPR146 (G Protein-Coupled Receptor 146) is a class A orphan G protein-coupled receptor (GPCR) . GPR146 is encoded by the GPR146 gene located on human chromosome 5 (5q12.1) and is broadly expressed in metabolic tissues, including the liver, pancreas, and adipose tissue, suggesting potential roles in energy homeostasis.Emerging evidence links GPR146 to lipid and glucose metabolism. For instance, in vivo studies in rodents indicate that GPR146 knockdown reduces plasma cholesterol and triglyceride levels, implicating it in lipid regulation. Additionally, GPR146 may modulate insulin secretion via interactions with pancreatic β-cells, hinting at relevance in diabetes pathophysiology. (PubMed,31778654, PubMed, 38503280)
Product Specifications
Background
Specifications
This protein carries a polyhistidine tag at the N-terminus and a Flag tag at the C-terminus. The protein has a calculated MW of 42.3 kDa.
Expression Region
Trp 2 - Ala 333
Target
GPR146
Conjugation
Unconjugated
Tag
N-10xHis & C-Flag
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Purity
90%
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Molecular Weight
42.3 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Host or Source
E. coli
Species
Human
Protein ID
Q96CH1-1
Preservative
Glycerol
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