Mouse IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag (MALS & SPR verified)

Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL13Ra1 to form the type II receptor which is responsive to both IL4 and IL13. Interleukin-4 receptor has been shown to interact with SHC1.

Product Specifications

Background

Specifications

Mouse IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag, produced by co-expression of IL-4 R alpha and IL-13 R alpha 1, has a calculated MW of 29.6 kDa (IL-4 R alpha) and 41.2 kDa (IL-13 R alpha 1) . Subunit IL-4 R alpha is fused with a polyhistidine tag at the C-terminus, and subunit IL-13 R alpha 1 contains a polyhistidine tag at the C-terminus. The protein migrates as 38-43 kDa and 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Ile 26 - Arg 233 & Ala 26 - Thr 340

Target

IL-4 R alpha & IL-13 R alpha 1

Conjugation

Unconjugated

Tag

C-10xHis | C-10xHis

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.