Human Betacellulin Protein, Research Grade
Betacellulin (BTC) is a member of the epidermal growth factor family that is comprised of at least ten proteins including EGF, TGF-alpha, amphiregulin, HB-EGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. Betacellulin is expressed predominantly in the human pancreas and induces the differentiation of a pancreatic acinar cell line (AR42J) into insulin-secreting cells, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture.
Product Specifications
Background
Specifications
Expression Region
Asp 32 - Gln 118
Target
Betacellulin
Conjugation
Unconjugated
Tag
Native
Stability
Endotoxin
0.01 EU per μg
Purity
95%
Format
Powder
Buffer
20 mM Citric acid, pH2.2
Molecular Weight
9.9 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
50ug*1
Host or Source
E. coli
Species
Human
Protein ID
P35070-1
Preservative
Trehalose
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