Human IL-36 gamma / IL-1F9 Protein, Tag Free (MALS verified)

The IL-36 subfamily of cytokines is the most diverse, including three agonists (IL-36α, IL-36β, and IL-36Γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory protein (IL-1RAcP) . The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. IL-36γ that binds to and signals through the IL-36R which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Appropriately balanced IL-36 signaling is a critical determinant of skin and lung health.