Human Parkin Protein, His Tag
Parkin is an E3 ubiquitin ligase encoded by the PARK2 gene, comprising 465 amino acids and containing an N‑terminal ubiquitin‑like domain and C‑terminal RING domains. It plays a pivotal role in the ubiquitin–proteasome system, tagging damaged or misfolded proteins for degradation. Parkin is essential for mitophagy, the selective clearance of dysfunctional mitochondria, thereby maintaining cellular homeostasis. Mutations in PARK2 cause autosomal recessive juvenile Parkinson’s disease, leading to dopaminergic neuron loss. Beyond neuroprotection, Parkin influences apoptosis regulation and cellular stress responses. Its dysfunction is linked to mitochondrial impairment, protein aggregation, and neurodegeneration, making it a key target in Parkinson’s disease research
Product Specifications
Background
Specifications
Expression Region
Ile 2 - Val 465
Target
Parkin
Conjugation
Unconjugated
Tag
N-10xHis
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Purity
85%
Format
Liquid
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Molecular Weight
53.5 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
500ug*1
Host or Source
InsectCells
Species
Human
Protein ID
O60260-1
Preservative
Glycerol
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