Human FGF19 Protein, Mouse IgG2a Fc Tag
Fibroblast Growth Factor 19 (FGF19) is a hormone belonging to the FGF family, encoded by the FGF19 gene. It is primarily synthesized and secreted in the ileum in response to bile acid absorption, acting as a ligand for the farnesoid X receptor (FXR) . FGF19's core function is to exert negative feedback on hepatic bile acid synthesis by binding to the Fibroblast Growth Factor Receptor 4 (FGFR4) /Klotho-β complex in the liver, thereby inhibiting cholesterol 7α-hydroxylase (CYP7A1) . Additionally, it plays a role in glucose and lipid metabolism. Its mouse ortholog is FGF15, and they are often referred to collectively as FGF15/19. Altered FGF19 levels are implicated in chronic bile acid diarrhea and certain metabolic disorders.
Product Specifications
Background
Specifications
Expression Region
Leu 25 - Lys 216
Target
FGF19
Conjugation
Unconjugated
Tag
C-mFc (mIgG2a)
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Molecular Weight
48.3 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
O95750-1
Preservative
Trehalose
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