Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11)
Selected Variant
PNU-MY2372-1mg
Size: 1 mg
PNU-159682 is a topoisomerase II inhibitor serving as a payload for antibody-drug conjugates (ADCs) . Its mechanism of action involves stabilizing the complex formed by topoisomerase II and DNA, blocking DNA repair and replication processes, and thereby inducing cancer cell apoptosis. Some ADCs containing PNU-159682 have entered the preclinical research stage, showing targeted killing activity in solid tumor models, with particularly significant effects on tumors with high topoisomerase II expression.
Product Specifications
Background
Target
PNU-159682
Conjugation
Unconjugated
Tag
Rabbit IgG | Rabbit Kappa
Stability
Format
Powder
Buffer
PBS, pH7.4
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Host or Source
HEK293
Species
Rabbit
Preservative
Trehalose
Price
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