Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11)

PNU-159682 is a topoisomerase II inhibitor serving as a payload for antibody-drug conjugates (ADCs) . Its mechanism of action involves stabilizing the complex formed by topoisomerase II and DNA, blocking DNA repair and replication processes, and thereby inducing cancer cell apoptosis. Some ADCs containing PNU-159682 have entered the preclinical research stage, showing targeted killing activity in solid tumor models, with particularly significant effects on tumors with high topoisomerase II expression.