PE-Labeled Human HLA-A*33:03&B2M&EGF R (HVKITDFGR) Tetramer Protein

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4) . Mutations affecting EGFR expression or activity could result in cancer. The Human HLA-A*3303 & B2M & EGF R (HVKITDFGR) protein is a complex of HLA-A*3303 of the MHC Class I, B2M, and HVKITDFGR peptide of the EGF R.

Product Specifications

Background

Specifications

PE-Labeled Human HLA-A*33:03&B2M&EGF R (HVKITDFGR) Tetramer Protein is assembled by biotinylated monomer and streptavidin. Biotinylated Human HLA-A*33:03&B2M&EGF R (HVKITDFGR) Complex Protein is produced by co-expression of HLA-A*33:03 and B2M loaded with EGF R peptide. Biotinylated Human HLA-A*33:03&B2M&EGF R (HVKITDFGR) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.5 kDa and 15.5 kDa.

Expression Region

Gly 25 - Ile 308 (HLA-A*33:03) & Ile 21 - Met 119 (B2M) & HVKITDFGR peptide

Target

HLA-A*3303 & B2M & EGF R (HVKITDFGR)

Conjugation

PE Labeled

Tag

C-10xHis

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.