Human EDNRB Full Length Protein, His, Flag Tag (Detergent)
Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR) . Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.
Product Specifications
Background
Specifications
This protein carries a polyhistidine tag at the N-terminus and a Flag tag at the C-terminus. The protein has a calculated MW of 49.7 kDa.
Expression Region
Glu 27 - Ser 442
Target
EDNRB
Conjugation
Unconjugated
Tag
N-6xHis & C-Flag
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Purity
90%
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, pH7.5, CHS
Molecular Weight
49.7 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
500ug*1
Host or Source
E. coli
Species
Human
Protein ID
P24530-1
Preservative
Glycerol
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