PHERV-W Envelope protein, His Tag

Dengue virus envelope (E) glycoprotein is a class II fusion protein mediating viral attachment and entry. Organized as dimers on the virion surface, it binds host receptors and, upon endosomal acidification, undergoes dramatic conformational rearrangements to drive membrane fusion. Structurally, E comprises three domains (DI, DII, DIII), with DIII responsible for receptor recognition. Highly immunogenic, E elicits neutralizing antibodies and is the principal target for vaccine design and therapeutic antibody development, as inhibiting its fusogenic transition blocks dengue virus infection.