Human PTP4A3 Protein, His Tag (MALS verified)
PTP4A3 (Protein Tyrosine Phosphatase 4A3) is an oncogenic phosphatase that promotes tumor metastasis by enhancing cell migration, invasion, and survival. It is overexpressed in multiple cancers (e.g., breast, ovarian, colorectal) and correlates with poor prognosis. PTP4A3 activates Rho GTPases and downstream pathways (ROCK/LIMK/cofilin) to remodel the actin cytoskeleton, facilitating cancer cell dissemination. Its dual cysteine-based catalytic domain dephosphorylates key signaling proteins, driving aggressive phenotypes. Targeting PTP4A3 offers therapeutic potential for inhibiting metastasis.
Product Specifications
Background
Specifications
Expression Region
Ala 2 - Cys 170
Target
PTP4A3
Conjugation
Unconjugated
Tag
N-10xHis
Stability
Purity
90%
Format
Powder
Buffer
PBS, 0.2 M Arginine, pH7.4
Molecular Weight
21.1 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*1
Host or Source
E. coli
Species
Human
Protein ID
O75365
Preservative
Trehalose
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