PE-Labeled Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Tetramer Protein

Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC) . Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC) . Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. The Human HLA-A*0201 EBV LMP1 (YLLEMLWRL) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M and YLLEMLWRL peptide of the EBV LMP1.

Product Specifications

Background

Specifications

PE-Labeled Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Tetramer Protein is assembled by biotinylated monomer (HLP-H82Ec) and PE-labeled streptavidin. Biotinylated Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Complex Protein is produced by co-expression of HLA and B2M loaded with EBV LMP1 peptide. Biotinylated Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) .

Expression Region

Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & YLLEMLWRL peptide

Target

HLA-A*0201 & B2M & EBV LMP1 (YLLEMLWRL)

Conjugation

PE Labeled

Tag

C-10xHis

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.