PE-Labeled Human HLA-A*11:01&B2M&KRAS (VVVGAGGVGK) Tetramer Protein

The Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) oncogene plays a critical role in the initiation and maintenance of pancreatic tumors and its signaling network represents a major target for therapeutic intervention. The Biotinylated Human HLA-A*1101 KRAS (VVVGAGGVGK) complex protein is a complex of HLA-A*1101 of the MHC Class I, B2M, and VVVGAGGVGK peptide of the KRAS.

Product Specifications

Background

Specifications

PE-Labeled Human HLA-A*11:01&B2M&KRAS (VVVGAGGVGK) Tetramer Protein is assembled by biotinylated monomer (HLS-H82E6) and PE-labeled streptavidin. Biotinylated Human HLA-A*11:01&B2M&KRAS (VVVGAGGVGK) Complex Protein is produced by co-expression of HLA and B2M loaded with KRAS peptide. Biotinylated Human HLA-A*11:01&B2M&KRAS (VVVGAGGVGK) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) .

Expression Region

Gly 25 - Thr 305 (HLA-A*11:01) & Ile 21 - Met 119 (B2M) & VVVGAGGVGK peptide

Target

HLA-A*1101 & B2M & KRAS (VVVGAGGVGK)

Conjugation

PE Labeled

Tag

C-10xHis

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.