APC-Labeled Mouse H-2Db&B2M&TRP1 (TAPDNLGYA) Tetramer Protein

TRP1 refers to tyrosinase-related protein. TRP1 is encoded by the TYRP1 gene. It is the human homologue of the brown (b) -locus in mice, the corresponding protein of which is associated with melanogenesis and pigmentation disorders of the skin. The exact function of TRP1 is still unknown. Besides its enzymatic activity, it may also play a structural role in the melanosome. TYRP1 is involved in the production of eumelanin, but it has also been implicated in the maintenance of the ultrastructure of melanosomes, melanocyte proliferation, and apoptosis. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) .

Product Specifications

Background

Specifications

APC-Labeled Mouse H-2Db&B2M&TRP1 (TAPDNLGYA) Tetramer Protein is assembled by biotinylated monomer and APC-labeled streptavidin. Biotinylated Mouse H-2Db&B2M&TRP1 (TAPDNLGYA) Complex Protein is produced by co-expression of H-2Db and B2M loaded with TRP1 peptide. Biotinylated Mouse H-2Db&B2M&TRP1 (TAPDNLGYA) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) .

Expression Region

Gly 25 - Val 309 (H-2Db) & Ile 21 - Met 119 (B2M) & TAPDNLGYA peptide

Target

H-2Db & B2M & TRP1 (TAPDNLGYA)

Conjugation

APC Labeled

Tag

C-10xHis

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.