Anti-TREM2 Antibody

Our Anti-TREM2 primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse TREM2 and is antigen affinity purified from pooled serum. It is great for use in WB, ICC.

Product Specifications

Background

Triggering receptor expressed on myeloid cells 2, TREM2, is a type I transmembrane innate immune receptor predominantly expressed by microglia in the central nervous system and is genetically linked to the risk for Alzheimer’s disease (Schmid, C.D., et al., 2002) . TREM2 has been shown to be a specific marker for alternatively activated microglia known as M2 cells (Cherry, J.D. et al., 2014) . TREM2 binds to its adaptor, DNAX-activating protein (DAP12) on the surface of microglia to enact innate immune responses and downstream cellular responses or signaling pathways (Jay, T.R, et al., 2017) . TREM2 has important roles in microglial phagocytosis of apoptotic neurons, damaged myelin, and amyloid plaques (Gratuze, M., et al., 2018) . In early brain development, TREM2 is essential for synaptic pruning (Filipello, F. et al., 2018) .

Synonyms

Triggering receptor expressed on myeloid cells 2

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

TREM2

NCBI Gene ID

54209

UniProt

Q9NZC2

Host

Rabbit

Reactivity

Mouse

Immunogen

Recombinant human TREM2 protein expressed in and purified from E. Coli.

Immunogen Type

Human

Target

TREM2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB, ICC

Concentration

Lot Dependent

Format

Antigen Affinity Purified from Pooled Serum

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Molecular Weight

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.