Anti-Synaptobrevin (VAMP) Antibody

Our Anti-Synaptobrevin (VAMP) primary antibody from PhosphoSolutions is mouse monoclonal. It detects bovine, human, mouse, pig, rat, rabbit, and hamster Synaptobrevin (VAMP) and is IgM purified culture supernatant. It is great for use in WB, IHC.

Product Specifications

Background

Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004) . Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive deficits in Alzheimer’s disease (Sze et al., 2000) .

Synonyms

SYB antibody, SYB1 antibody, Synaptobrevin 1 antibody, VAMP antibody, VAMP1 antibody, Vesicle associated membrane protein 1 antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

VAMP1/2

NCBI Gene ID

6843

UniProt

P23763

Host

Mouse

Reactivity

Bovine, Human, Mouse, Pig, Rat, Rabbit, and Hamster

Immunogen

Synaptic immunoprecipitate (crude) from human brain.

Immunogen Type

Human

Target

Synaptobrevin (VAMP)

Clonality

Monoclonal

Clone

SP10

Conjugation

Unconjugated

Applications

ELISA, WB, IHC

Concentration

1 mg/ml

Format

IgM Purified culture supernatant

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Molecular Weight

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

IHC Dilution

1:100

WB Dilution

1:1000

Specificity

Specific for endogenous levels of the ~16 kDa synaptobrevin. The antibody has also been demonstrated to work in immunohistochemistry on formalin fixed, vibratome sections, but does not work on paraffin sections.