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Anti-Retinoic Acid Receptor, α-Isotype Antibody

Our Anti-Retinoic Acid Receptor, α-Isotype primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse and rat Retinoic Acid Receptor, α-Isotype and is Protein G purified. It is great for use in WB.

Product Specifications

Background

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .

Synonyms

NR1B1 antibody, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody, Nuclear receptor subfamily 1 group B member 1 antibody, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody, RAR alpha antibody, RAR antibody, RAR-alpha antibody, rara antibody, RARA_HUMAN antibody, RARalpha antibody, RARalpha1 antibody, Retinoic acid nuclear receptor alpha variant 1 antibody, Retinoic acid nuclear receptor alpha variant 2 antibody, Retinoic acid receptor alpha antibody, Retinoic acid receptor alpha polypeptide antibody

Other Statements

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Gene Name

RARA

NCBI Gene ID

5914

UniProt

P10276

Host

Mouse

Reactivity

Human, Mouse and Rat

Immunogen

Synthetic peptide corresponding to amino acid residues from the N-terminal region of human retinoic acie receptor, α-isotype, conjugated to keyhole limpet hemocyanin (KLH) .

Immunogen Type

Human

Target

Retinoic Acid Receptor, α-Isotype

Clonality

Monoclonal

Clone

763

Conjugation

Unconjugated

Applications

ELISA, WB

Concentration

0.5 mg/ml

Format

Protein G Purified

Form

Liquid

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Molecular Weight

48

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

WB Dilution

1:1000

Specificity

Specific for endogenous levels of the ~48 kDa RAR-α isotype.

Formulation

Prepared from tissue culture supernatant by ammonium sulfate precipitation followed by purification on a Protein G column.

Quality Control

Western blots performed on each lot.

Species

Bovine, Canine, Guinea Pig

Isotype

IgG1

Curated Selection

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